To tell friends and family about their naloxone and to maintain it in a spot wherever family and friends can accessibility it within an emergency,
Emphasize to individuals as well as their caregivers the significance of examining the Medication Guidebook that they will obtain from their pharmacist anytime an opioid analgesic is dispensed to them.
Use: For your management of mild to average agony where by remedy using an opioid is appropriate and from which alternative treatments are insufficient.
Get health care aid right away for those who see any of the subsequent: gradual/shallow respiration, critical drowsiness/problems waking up, confusion.
Acetaminophen and codeine may perhaps lead to serious hypotension including orthostatic hypotension and syncope in ambulatory individuals. You can find improved hazard in clients whose potential to maintain hypertension has previously been compromised by a reduced blood quantity or concurrent administration of certain CNS depressant medications (e.g., phenothiazines or general anesthetics) (see PRECAUTIONS, Drug Interactions).
Codeine crosses the blood-Mind barrier which is present in fetal tissue and breast milk. The plasma concentration won't correlate with brain concentration or aid of soreness. Codeine is about 7 to twenty five% bound to plasma proteins and does not accumulate in system tissues.
If concomitant use with CYP2D6 inhibitors is necessary, evaluate the affected individual for decreased efficacy or signs and symptoms of opioid withdrawal and think about growing the acetaminophen and codeine phosphate tablets as required.
Reserve concomitant prescribing of acetaminophen and codeine phosphate tablets and benzodiazepines or other CNS depressants to be used in people for whom alternative treatment choices are inadequate (see PRECAUTIONS, Drug Interactions).
If concomitant use is warranted, usually Appraise the client, specially all through therapy initiation and dose adjustment. Discontinue acetaminophen and codeine phosphate tablets instantly if serotonin syndrome is suspected.
Drink alcohol or use prescription or more than-the-counter medicines that include alcohol. Applying products and solutions made up of alcohol throughout therapy with acetaminophen and codeine phosphate tablets could result in you to definitely overdose and die.
Go over With all the client and caregiver The supply of naloxone to the unexpected emergency cure of opioid overdose, both of those get more info when initiating and renewing cure with acetaminophen and codeine phosphate tablets. Advise clients and caregivers about the different ways to obtain naloxone as permitted by specific point out naloxone dispensing and prescribing prerequisites or rules (e.
Instruct individuals to discontinue acetaminophen and codeine phosphate tablets immediately and search for more info health-related care when they experience these signs or symptoms. Usually do not prescribe acetaminophen and codeine phosphate tablets for patients read more with acetaminophen allergy (see Safety measures, Data for Individuals/Caregivers).
Examine sufferers receiving check here acetaminophen and codeine phosphate tablets and any CYP3A4 inhibitor read more or inducer for symptoms and signs and symptoms which could reflect opioid toxicity and opioid withdrawal when acetaminophen and codeine phosphate tablets are utilised in conjunction with inhibitors and inducers of CYP3A4 (see Safety measures, Drug Interactions).
Get crisis help or contact 911 straight away if you're taking a lot of acetaminophen and codeine phosphate tablets (overdose). If you initially start out using acetaminophen and codeine phosphate tablets, Whenever your dose is transformed, or if you take excessive (overdose), critical or lifetime-threatening respiration issues that can result in Loss of life might happen.